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Complementary Anti-Inflammatory Profiles: Their combined action may reduce systemic inflammation while promoting regenerative cytokines, creating a favorable environment for healing

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Opportunities for progress include rational brain-exposure design with efflux avoidance, development of microglia-directed delivery systems, and incorporation of human target-engagement biomarkers into early-phase studies

Significantly, as shown in Figure 6 in their Extended Data (9), Gordon et al

Possibly, the melatonin receptors MT1 and MT2 are involved in the modulation of this outcome

Hypertension 16 , 363370 (1990)